Professor Lu Ying Li from the department of endocrinology made a major achievement in SPECT - China's large epidemiological investigation progress

  Professor Lu Ying Li from the department of endocrinology of shanghai ninth people‘s hospital affiliated to shanghai jiao tong university school of medicine made a major achievement in SPECT - China’s large epidemiological investigation progress. The survey aims to study metabolic disease and its risk factors in east China. Professor Lu Ying Li and his team has published more than 10 SCI papers, including two of the papers published in the endocrine Clinical top magazine in the Journal of Clinical Endocrinology & Metabolism “(J Clin Endocrinol Metab), a paper published in the” Science “magazine owned by Scientific Reports.

  The survey found that fetal and childhood experience famine caused by malnutrition and adulthood rapid economic development to increase risk of diabetes in adulthood, and this result may have to do with the older people (especially the 52-65) in China that is related to the rapidly rising prevalence. Endocrine Clinical studies published in full in such top Journal of Clinical Endocrinology & Metabolism (J Clin Endocrinol Metab, 2015 Oct 28: jc20152750), and results are introduced in Reuters (Reuters), and Yahoo, Channel NewsAsia, AG week and other websites.

  The problem in China in the year of 1959 and 1962 was the worst in the world and had influenced the largest number of great famine, and rapid economic development since the reform and opening up since 1978, per capita GDP from $28 to $6807 in 2013. In this process, the high incidence of diabetes appears a gradually popular trend. The purpose of this study is to explore or prenatal malnutrition in children and adult experience of life to improve economic development whether to increase risk of diabetes. Samples from the 2014 China, especially the east China investigation and study of metabolic disease and its risk factors. The study was conducted in Shanghai, zhe jiang and Jiang Xi zhong and other 16 sites, which included 6899 cases of the sample. The fetus and childhood diabetes risk following exposure to famine increased 53% and 53% respectively. And rapid economic development into adulthood crowd the diabetes risk further increased by 46%. The results suggest diabetes prevention should begin from the maternal and infant stage begins.

  In addition, the survey also found that early life experience famine occurred in adulthood correlation nonalcoholic fatty liver disease, nonalcoholic fatty liver disease including liver disease, which includes more than 5% of the liver cells of simple fatty infiltration (steatosis), fatty infiltration and inflammation, fibrosis and cirrhosis. Nonalcoholic fatty liver disease in many developed countries and developing countries has rapidly become the most common cause of abnormal liver biochemistry. In parts of China, the prevalence of nonalcoholic fatty liver disease has reached about 40%. In the United States, nonalcoholic fatty liver disease in the general population prevalence rate is about 30%. Chinese patients with nonalcoholic fatty liver disease surge phenomenon cannot be simply explained by the rapid development of the economy for decades.

  At the same time, the differences between men and women, the correlation among women, prenatal and childhood famine malnutrition may be a risk factor for moderately severe fatty liver, increased risk in the unexposed group 77% and 82% respectively; But in men, the correlation was not significant, and it may be associated with survival choice and the patriarchal culture. This research was published in full length in Clinical Endocrinology & Metabolism (J Clin Endocrinol Metab, 2016 MAY: jc. 2016-1076), a top Journal in endocrine Clinical.