|Nature series magazine published research results of new cancer hunger therapy from Cell|
metabolism and diseases department of Clinical translation center from Shanghai No.1 hosptial
Hunger therapy in the field of cancer treatment has always been considered a promising treatment strategy, but limited to cells themselves to “hunger” state of self-protection. The actual effect has not been very ideal. Recently, according to a study by a subsidiary joint of east China normal university, researchers conducted studies and confirmed that a proteasome is called REG gamma cells “self protection” key ingredient to starvation. Knocking “low” REG gamma can significantly improve the energy metabolism inhibitors antitumor activity in mice, and this means that REG gamma proteasome is hunger tumor treatment which is a potential therapeutic targets. The findings were published in the August 11, the Nature Communications journal (Nature Communications). Sun Lianhui, Fan Guangjian, ChanPeiPei from Shanghai No.1 hospital affiliated clinical translantion research institute of cell metabolism and disease, are the first authors, and professor chuan-gui wang and Dr Zhang Shengping areshared corresponding authors of this paper.
Shanghai No.1 hospital clinical translation center participates in this topic research institute of cell metabolism and disease expert introduction. They believe that hunger therapy is conducted by injecting a 2 - DG (double deoxidizing glucose) to implement the simulation of energy limit, in order to make tumor cells intake of glucose decreased dramatically. Cancer because of sugar consumption is much larger than normal cells, so this method can be targeted to “starve” cancer cells, and less damage to normal cells. In this process, however, REG gamma protease can inhibit cell internal friction process and maintain energy balance and cell survival - this originally isthe means of self-protection in human body, to starvation hunger but in tumor therapy, this factor has become a “counterproductive”.
The experts found that low REG gamma can significantly improve the energy metabolism inhibitors antitumor activity in mice, which is equivalent to a “counterproductive” activation factor a kick open, by raising the therapy effect of hunger. Results illustrate in hungry condition to maintain energy balance and cell vitality of a non ubiquitin dependent control mechanism of the process, and it shows that REG gamma proteasome is hunger tumor treatment which is a potential therapeutic targets.
This paper corresponding author professor chuan-gui wang spent nearly five years in stress, tumor cells and metabolic disorders as well as many other innovative achievements. Chuan-gui wang and Zhang Shengping found in 2015 that showing the lipid metabolism regulation gene is a new tumor suppressor of genome stability control. The gene is expected to become the tumor diagnosis and treatment and anti-tumor drugs research and development of new targets (2015) study, which was published in Nature Communications. Xiao-tao liand chuan-gui wang confirmed that the proteasome activation factor REG gamma inhibit autophagy regulating liver lipid metabolism. REG gamma was revealed in the role of autophagy and liver fat, protease and autophagic degradation system happened in lipid homeostasis mechanism on mutual crosstalk. The findings, were published in Cell Metabolism, and Nature Medicine designed evaluation.