Translational medicine research team from Ruijin hospital made new progress

  Recently, Professor Zhu Zhenggang and Professor Yu Yingyan from the Shanghai institute of digestive surgery, and translational medicine research team from Shanghai Ruijin hospital found the latest urine biomarkers of cancer of the stomach. The results of the study was published on the international authority of cancer research Oncotarget. These newly found urine small molecule compounds compared with traditional serum tumor markers, shows a better sensitivity and specificity. The work improves gastric cancer early detectionfor realizing the “noninvasive” diagnosis of gastric cancer, and early treatment is of positive significance.

  Gastric carcinoma is a malignant tumor of high incidence and mortality of digestive system, and in China, the high incidence of gastric cancer is due to the lack of specificity of the early clinical symptoms, which are often found to have reached a period, at the optimal timing of surgery. Ruijin hospital team focused on cancer research which has long been ignored in the field of biological samples, urine, along with the development of metabonomics in the world with the rise of the researchers who noticed that when the body disease (refers to the metabolic disease) also can appear metabolites spectrum disorder, and it inspired the team innovation thinking: in patients with gastric cancer whether there is such a unique spectrum of metabolites?

  Metabolites are the final breakdown products of human life activities, which belong to small molecules. The original testing equipment can‘t test small molecular compounds. Ruijin hospital gastric cancer translational medicine research team from the beginning attempts establish analysis method, to collect the sample, and with the aid of Shanghai jiaotong university in science and engineering discipline advantage, Shanghai jiaotong university with precision instruments in the field of analytical chemistry (gas chromatography/mass spectrometry (GC - MS), first in the first round of the 90 cases of urine samples was carried out by early screening. They found in the urine composed of more than 100 kinds of small molecular compound metabolites. With this new discovery, research team furthered to use optimization analysis and data mining method, with the locking of 17 potential of small molecules, the expansion of samples and 200 patients with quantitative analysis. They finally found a total of 14 amino acids and organic acids small molecule compounds that have biological significance.These newly found urine small molecule compounds as gastric cancer tumor markers and serum tumor markers, analysis of traditional showed the good sensitivity and specificity. There are three kinds of small molecules in the urine associated with adverse prognosis of gastric carcinoma.

  It is reported that earlier research has cancer of the stomach blood marker research results included in the construction of Shanghai science and technology innovation center the first patent, kit by zhangjiang intellectual property operating platform to buy and the preparation and approval. At this time, focus on the urine small molecular markers of innovative discovery from stomach cancer has applied for national invention patents. New team is currently working on urine small molecular markers of clinical practical detection methodology exploration, and they make the collection of medical professionals, so that medical discipline research results will soon realize the transformation, the benefit of patients.

  The project got the national high technology research program (863), the national natural science funds, science and technology commission of Shanghai scientific research funds, Shanghai jiaotong university medical professionals cross innovation fund, Shanghai jiaotong university school of medicine translational medicine innovation fund, etc. The first author of the article are Dr. Cheng Yinan and Dr. Zhangjun from ruijin hospital of general surgery; Corresponding authors areProfessor Zhu Zhenggang and Professor Yu Yingyan.