|Fang Jingyuan from Renji hospital revealed LncRNA GClnc1 might be involved in gastric cancer for the first time in the world|
Recently, the national institute of Cancer research (AACR) its top journals “Cancer Discovery” (the latest impact factor is 19.8) published a scientific result from Renji hospital affiliated to Shanghai jiaotong university school of medicine and the university of Michigan cooperation entitled “LncRNA GClnc1 promotes gastric carcinogenesis and may act as a modular scaffold of WDR5 and KAT2A complexes to specify the histone modification pattern” of research results. This paper also got the same guest editor review. In this paper, corresponding authors professor Fang Jingyuan HongJie and Chen Haoyan are from Renji hospital affiliated to Shanghai jiaotong university school of medicine, and associate researcher Zou weiping from the university of Michigan. The first author is Sun Tiantian, a doctoral student of professor Fang.
According to the corresponding author, professor Fang Jingyuan director of the digestive department of Renji Hospital introduced the mechanism of gastric cancer are very complex, at present the world within the scope of the research mainly focuses on gastric cancer early warning and predict prognosis even find new targets for the prevention and treatment, etc. Although, in the industry known long non-coding RNA (lncRNA) can work through a variety of broad participation and development of tumor, but its role in gastric cancer is not yet clear. This clinical significance of the research mainly includes the following three aspects: one is the first time will be long noncoding RNA GClnc1 as a biomarker of independence, to predict the occurrence and prognosis of gastric cancer; 2 it is the first time found in gastric cancer from mild - the process of the development of moderate to severe precancerous lesions, long noncoding RNA GClnc1 expression quantity is increase, compared with the traditional technology, good long noncoding RNA detection specificity, prompt the predictors may be the stomach precancerous lesion in the development of one of the independent diagnosis; Third, the study found for the first time long noncoding RNA GClnc1 can be independent of the TNM staging to forecast the prognosis of gastric cancer patients. With conventional TNM staging tumor prognosis prediction of general use to compare and reveal the amount can be expressed by GClnc1 determination can be used to predict the prognosis of the tumor patient,,
Fang Jingyuan team concluded through the analysis of the tranome chip. They first discovered lncRNA GClnc1 high expression in gastric cancer organizations. Clinical analysis of research shows that GClnc1 participates in the occurrence of gastric cancer, tumor volume increase and distant metastasis, reveal GClnc1 expression is closely related to the prognosis of gastric cancer. Discovery further mechanism, molecular WDR5 GClnc1 as scaffolding molecules affect histone modification and KAT2A combination and histone modification adjustment, which involved in tumorigenesis of downstream genes (for example: SOD2) activation and function.
Long noncoding RNA GClnc1 the study is the first time in its regulatory role in the development of gastric cancer and its effect on the new way, to provide a significant role in the development of the new way of thinking. Fang jingyuanand his team look for more likely to be involved in occurrence and development of the digestive tract tumor long noncoding RNA, for the diagnosis and treatment of digestive tract tumor more breakthroughs and hope. This study is carried out by NSFC project innovation research groups, NSFC major, the superior NSFC green and NSFC projects such as multiple fund project funding support, the first author and the main corresponding author units also come from Renji hospital digestive department.