|Young teacher Wang Yiping published research of tumor metabolism on Molecular Cell|
On November 11, from basic medical college hospital department of Cell biology, biochemistry and Molecular, young teacher Wang Yipingworked as the first author and published in international Molecular biology heavyweight journal Molecular Cell (IF: 14) titled “Arginine Methylation of MDH1 by CARM1 InhibitsGlutamine Metabolism and Suppresses PancreaticCancer”. The study found that the enzyme CARM1 arginine methylation can on malate dehydrogenase MDH1 methylation modification and reduce its activity, thereby inhibiting pancreatic cancer cells of glutamine metabolic process, reveals the tumor cell metabolism and characteristic, new to the clinical application of tumor metabolic regulation has important guiding significance.
Pancreatic cancer is known as the “king of the cancer,” its five-year survival rate is only 3% to 5%. Recent research suggests that pancreatic cancer cell proliferation is highly dependent on glucose and glutamine. It is important to note that, unlike other cancer cells, pancreatic cells have adopted a unique glutamine metabolic pathways, but in the past to the regulatory mechanism of this approach is not clear. Dr Wang Yiping work reveals the regulation: pancreatic cancer glutamine metabolic pathways of malate dehydrogenase MDH1 modified by arginine methylation, methylation modification can inhibit MDH1 polymerization and thus its catalytic activity. Further study found that protein arginine methyl transferase PRMT4 (also called CARM1) is responsible for the catalytic MDH1 methylation process, and reduce the glutamine utilization in pancreatic cancer cells, inhibition of cell proliferation. More importantly, in clinical pancreatic cancer tissues, CARM1 show lower expression state; Corresponding MDH1 low methylation status, has high catalytic activity, suggests that MDH1 methylation regulation is a potential therapeutic targets pancreatic cancer.
Dr. Wang Yiping In 2014 graduated from biomedical research institute of Fudan University. In the same year he entered the basic medical department of cell biology, biochemistry and molecular of jinkecheng laboratory as a young teacher. He mainly engaged in the metabolism of tumor research. In 2014 and 2015, he respectively, published the corresponding research resultsin the EMBO and Molecular Cell magazine. The research is published under the leadership of the fudan university professor qun-ying lei. Doctor Zhou Wei was involved in the metabolic flow analysis. The study got support and assistance from Professor Su Bing team,professorLiu Yingbin from xinhua hospital and Professor ZouShaowu from the tenth people‘s hospital professor team. The project received funding from the key project of national natural science foundation, national natural science foundation of youth and Shanghai young scholar projects.