|Xu Tianle and his group published an article on Nature Communications online|
On December 7, tian-le xu, from school of basic medicine, the department of anatomy and tissue embryo group and subsidiary Shanghai children‘s medical center / - environment and children’s health in Shanghai key laboratory of the ministry of education Li Fei chief physician team made cooperation in the latest research results of ASIC1a regulates insular long - term ‘and is required for the extinction of conditioned taste aversion in Nature Communications, published online (impact factor : 11.3).The results of the study by the underlying medical assistant researcher, associate researcher Dr Li Weiguang, ming-gang liu, shi-ning deng from Shanghai children’s medical center. The researchers used mice behavior analysis, virus fixed-point intervention and electrophysiological technique, reveals the acid sensitive ion channels (acid - sensing ion channel, ASIC) in the conditioned taste aversion to resolve the key role and its mechanism in the study.
As is known to all, anxiety, depression, post-traumatic stress disorder, anorexia, drug addiction and relapse is a major brain diseases such as serious damage to human health and social development, especially with the rapid economic development and people living pressure increasing and lifestyle change, make sustained growth has gradually become a disabling brain disease epidemic disease burden in the first place. A large number of brain disease for the above studies show that the mechanism of negative memory (aversive memory) of excessive reinforcement or cannot be effectively fade is likely to be the common basis of neurobiology. Conditioned taste aversion memory, for example, if not effectively fade, in the process of children‘s growth, food feeding correction will be prone to partial eclipse even the refractory feeding difficulties, on children’s physical and mental development will cause irreversible effects.
According to the above problem, in the national natural science fund committee “emotion and memory neural circuits base” major research plan, with the support of key support project researchers cooperation conducted pathological memory neural circuits and synaptic plasticity mechanism of ion channel research. Acid sensitive ion channels (asics) are widely distributed, the central and peripheral neurons is a kind of activated by extracellular protons (the hydrogen ions) cation channels (mainly appear a sodium ion). Tian-le xu team devoted to ASIC biological function and its mechanism of action research, used to reveal the ASIC in mediated acidification caused by nerve damage, and play an important role in chronic pain. In the first half of this year, tian-le xu group system illustrates the contribution cornu ammonis long cheng synaptic strengthening ASIC1a ion channels (long - term potentiation, LTP) the mechanism of plasticity (Sci Rep, 2016).
So in the new study, the researchers found, the central ASIC1a ion channels in taste - island cortex significant contribution to the long-term process of synaptic inhibition (long - term which LTD) plasticity, but had no significant effect about LTP; ASIC1a gene knockout or selective intervention in insula cortex ASIC1a, can make the animals in the taste aversion showed selective fading learning obstacles, but to get conditioned taste aversion memory, storage and extraction but no effect; Even more interestingly, experienced taste aversion regression study of animals, the island cortex excitatory synaptic strength decreased significantly, and cannot be further induced LTD. The above findings suggest that ASIC1a ion channels rely on the island of cortex LTD plasticity, may make up the taste aversion subsidise new cellular and molecular mechanism of learning, the study to cure or alleviate anorexia, anxiety, drug addiction, smoking and other associated with abnormal stubborn pathological memory neural system disease provides a new treatment idea and targets. Related research results have been applied for the Chinese invention patent.
The study received the ministry of science and technology project 973, the national natural science foundation of China and the United States national institutes of health (NIH) research funds and so on many project support, and “lift project” for young scientists of China association for science and technology, Shanghai young university orientalist, basic medical college of Shanghai jiaotong university funding support for excellent young university teachers plan. At the same time, also received the United States at the university of Texas Michael Xi Zhu and Taiwan yangming university professor Cheng Chang Lien.
The original link: http://www.nature.com/articles/ncomms13770